Oxidant-antioxidant status in chronic obstructive pulmonary disease: relationship with disease severity
Air pollution has major health impacts on people living in Ulaanbaatar. As written in the WORLD BANK report: Ambient annual average particulate matter concentrations in the capital of Mongolia are 10–25 times greater than Mongolian air quality standards and are among the highest recorded measurements in any world capital. Chronic obstructive pulmonary disease (COPD) induced by air pollution was found to be a major cause of illness in Mongolia .
Low body mass index has been associated with increased mortality in severe COPD. The impact of body composition earlier in the disease remains unclear. We studied the impact of body composition on the risk of functional limitation in COPD. We measured a wide range of parameters of the oxidant-antioxidant status in erythrocyte membrane, cytosol, plasma and urine of 196 patients with COPD and 80 healthy controls (HC). All data used in this paper is gathered since 2008 at the First National Central Hospital of Mongolia. Using the data mining methodology we selected highly effective features among them. Correlations between features were determined by SPSS 20. Also the results were analyzed using SPSS 20 for Windows; data are reported as mean, standard deviations and standard errors. The statistical significance was given by a p value<0.05.
An oxidant-antioxidant imbalance is thought to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We hypothesized that antioxidant capacity reflected by cytochrome c oxidase (COX), free radical scavenging substances (FRSC), and levels of the lipid peroxidation product malondialdehyde (MDA) in erythrocyte, plasma and urine may be related to the bronchial obstructive parameters in patients with COPD .
The findings of the present study suggest that antioxidant capacity reflected by COX and the lipid peroxidation products MDA in erythrocyte’s membrane are linked to the severity of COPD.
Body composition is an important non-pulmonary impairment that modulates the risk of functional limitation in COPD, even after taking pulmonary function into account. Body composition abnormalities may represent an important area for screening and intervention in COPD.
Key words: Chronic obstructive pulmonary disease, free radical scavenging activity, cytochrome c oxidase, Lipid peroxides products, Malondialdehyde