Affiliation: School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, China
Self-motivated Learning Grounds Competence Real-Time Cardiac Arrhythmia Detection
TRAIL receptor 5 (DR5, also named TRAIL-R2) locates at the cell surface, becomes activated or oligomerized upon binding to its ligand TRAIL or overexpression, and then signals apoptosis through caspase-8-mediated rapid activation of caspase cascades. While TRAIL is relatively non-toxic to normal cells, it can selectively induce apoptosis in many types of transformed cells. Nevertheless, some human bladder cancer cells are particularly resistant to the effects of TRAIL. Previous, we report has been shown to that in combination with the sevelal chemotherapeutics, exposure to TRAIL induced apoptosis in TRAIL-resistant cancer cells with no detectable inhibition of cell proliferation effects on normal cells. Following exposure to chemotherapeutics death receptor (DR5) proteins were significantly up-regulated in cancer cells. Indeed, knockdown of DR5 expression by siRNA attenuated chemotherapeutics plus TRAIL-induced apoptosis. However, the signaling mechanism of DR5 in TRAIL resistant human bladder cancer cells remains unclear. In this current study, we will seek to identify the functional roles of DR5 on the chemotherapeutics and TRAIL-sensitizing effects of cancer cells by use of specific over-expression of DR5 and DR5 deficient human bladder cancer cells and mice models. From this research, the novel roles of DR5 in the combination of TRAIL and therapeutics may be a safe strategy for treatment of resistant human bladder cancer cells.
ChengYun Jin is a Professor, now working at the department of Phamaceutical Science, Zhengzhou University, China. In 2003 and 2007, he received the M.s., and Ph.D. degree from Pusan National University, Korea, and then stared his post-doc Job in Department Research Group for Marine and Silver Biotechnology of Pusan National University (2007-2008), and Resources Development for Marine and Herbal Genome Materials of Dong-eui University (2008-2012). In 2012 he stayed at Department Medicine, Chungbuk National University as a invited associate professor. His research interest is apoptosis, metastasis focusing on the biochemical and molecular properties of anticancer compounds.